Synthesis and Biological Evaluation of 2,4-Diaminoquinazolines as Potential Antitumor Agents
نویسندگان
چکیده
In the present study, a set of 2-anilino-4-alkylaminoquinazoline derivatives were synthesized and tested for their antitumor activities in vitro against panel four human cancer cell lines DNA-binding affinity. Among compounds, 4c 5b with 4-substitution at phenyl ring found to have highest inhibitory effects breast adenocarcinoma (MCF-7), colon (HCT-116), hepatocellular carcinoma (HePG-2), skin (HFB4). Further investigation revealed that compounds 4a 5d exhibited better affinity bind DNA than other compounds.
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ژورنال
عنوان ژورنال: Journal of Chemistry
سال: 2022
ISSN: ['2090-9063', '2090-9071']
DOI: https://doi.org/10.1155/2022/7763545